It is a drug injection technique. It consists in the introduction of drugs through the skin, that is, in an intradermal fashion, which act by demonstrated tissue diffusion (through body tissues) over the receptors of the organ, tendon, muscle or joint where they will have their therapeutic action. Etymologically the term Mesotherapy derives from the Greek Mesos = in the middle, and therapy = treatment. It means: therapy within the mesoderm. The dermis derives from this embryonic layer, and there, with the assistance of a mesotherapy gun (mesogun), is where the drug will be deposited to act by tissue diffusion (through tissues). The other two remaining layers are the endoderm and the ectoderm.

Two terms, similar in Spanish, should be distinguished: the first is “masoterapia ”, which refers to a type of massage, and the second: “ mesoterapia ” is the injection technique. The origin of the word, given by its creator, is French. In that language “masaje” and “mésothérapie” respectively are well differentiated words, not giving rise to the confusion said terms produce in Spanish.

Mesotherapy is not a type of infiltration, given that no corticoids are used and it does not involve the possible risk of infections and crystallizations of intra-articular injections.

With Dr. De Biase next to a poster supporting that medications be prescribed by physicians. Here and anywhere else in the world prescribed drugs are safer than medications advised by publicity. Mesotherapy drugs should always be administered by physicians with enough knowledge of mesotherapy pharmacology.

How does mesotherapy act?

This intradermotherapy technique, mesotherapy, was developed by Dr. Michel Pistor, who defined it as “a new and simple therapeutic conception which takes the drug administration site as closely as possible to the disease location, introducing superficial intradermal or subcutaneous injectable doses of a minimal, locoregional nature”.
Dr. M. Pistor was a rural physician settled in Bray Lu, in the Oise Valley, France, who in 1952 began with the practice of intradermally injecting procaine, to which other drugs were later added, achieving results that surprised even him. He developed and named this technique Mesotherapy.

He makes reference to this kind of application in his axiom: “little, rarely and in the right site”. In this context little represents the minimal doses used in mesotherapy, rarely refers to the frequency of sessions every 7, 15 or 30 days one from the other, and in the right site implies the proximity of the therapy to the place where the disease is located. Many studies and literature back up this axiom. The conditions in which the mesotherapeutic act is performed, including single-use material both for manual and electronic gun-assisted applications, very fine needles and pharmacological knowledge, are pivotal to achieve painless applications with excellent tolerance and therapeutic response.

Mesogun. Mesotherapy guns: their assistance makes administration painless and gives precision regarding deepness and dosage per puncture. Dermis does not have the same thickness throughout the body: the skin of a finger differs from the skin of the knee or the back.

What drugs may be used?

Allopathic drugs (many of the ones listed in the Tratado de Farmacología Mesoterápica, Treatise of Mesotherapy Pharmacology), namely central action circulatory regulators (act on the C.N.S), peripheral circulatory regulators (they exert their regulatory influence over the upper and lower limbs), venous, arterial, lymphatic and even capillary regulators which will act over the microcircle located in the site of the disease to improve the supply of repairing elements and micronutrients required for biological recovery. Muscle relaxants especially designed for mesotherapy use, such as tiocolchicoside, provides very fast action (in minutes), lasting duration (for days) and local action. Analgesics and non-steroid anti-inflammatory drugs are also used for pain, neuralgias and sports injuries.

Specific therapies with a reducing and revitalizing effect exist for skin disorders such as cellulite, localized obesity or flaccidity. The desired effect will occur in the same place the drug is administered, that is, the skin itself. For example: lipolytic substances convert fats into glycerol which is removed in the urine, and glycerides pass onto the systemic circulation to be consumed. The introduction of homeopathic medications in localized medical treatments improves the efficacy and the chances of recovery. The fastness of action and the harmlessness of homeopathic medications provide a satisfactory response to acute disorders, and can be successfully complemented with the conventional MESO technique. In chronic conditions (diseases lasting months or years), administering dynamized homeopathic medications will provide relief or cure in a soft manner, with no side effects.


When may mesotherapy be indicated?

• Sports injuries: tendinitis, tears, ligamental injuries, sprains, spine disorders, slipped disc.
• Rheumatologic lesions: arthrosis, arthritis, osteoporosis, fibromyositis, chronic fatigue syndrome and myofascial syndrome. Osteochondritis.
• Neurological injuries: neuralgia, postherpetic and trigeminal neuralgia, sciatic neuralgic, headaches, vertigo, peripheral nerve compression, neuritis, cervicobrachialgia, pseudo-radiculalgia.

• Cellulite, spider burst veins, acne, hair loss, flaccidity, localized obesity, double chin.
• Exclusive revitalizing therapy for back of hands, neck and face; may be complemented with cosmetic treatments or plastic surgeries.

• Brain and limb circulatory insufficiency, chronic venous insufficiency, ulcers, diabetic foot, vision and memory loss, anti-stress therapy and gerontology.
• Mesovaccination with ribosomal vaccines in children and adults to raise the immune system defences. In adults, vaccines to prevent flu and pneumonia.
• Mesohomeopathy: thrush, allergies, acne, angina and other infections, anorexia, acidity, apnea, atherosclerosis, panic attacks, cramps, stones, cancer, headaches, cystitis, irritable colon, dentition, depression, flatulence, phlebitis, flu, hemiplegia, liver conditions, menopause, prostate, rhinitis, smoking, thyroid gland disorders, coughing, vertigo, etc.

To conclude: localized disorders are the primary indications for local treatment, in sites that can be reached by locoregional medication. There are other indications that, given their characteristics, go beyond the scope of this explanatory summary.